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Giant carcinosarcoma of the ovary. A case report and review of the literature

DOI: 10.17605/OSF.IO/MEKCB

Guerrero Caballero RJ, Lopez Plata Y, Flores Coutiño A. Giant carcinosarcoma of the ovary. A case report and review of the literature. Am J Med Surg. 2021; 5(2). 10-14.

BACKGROUND. Carcinosarcoma is defined as a mixed malignant proliferation formed by two contingents, one epithelial, the other mesenchymal, also known as malignant mixed Müllerian tumor, is one of the rarest histologic subtypes of the ovary, accounting for 1 to 4% of all ovarian tumors. OCS (Ovarian carcinosarcoma) can be found in the genitourinary tract, the most common site being the uterus, followed by the ovary, fallopian tubes, cervix, vagina, peritoneum, breast and urethra. The rarity of the disease generates much controversy about the histogenesis, prognostic factors and treatment of OCS. OCS is usually found after menopause, with a median age of 65 years. Risk factors are the same as for ovarian carcinomas and sarcomas: obesity, nulliparity, exogenous estrogens, radiation therapy, and prolonged use of tamoxifen. The clinical presentation is usually abdominal pain, early satiety, gastrointestinal dysfunction, depending on the size, to the point of causing intestinal occlusion.  The diagnosis of carcinosarcoma should be approached comprehensively. Symptoms, radiological findings and tumor marker levels should be taken into account. Almost all patients will express CA-125 antigen, at a value above 75 U/ml However, the final diagnosis can only be made after histopathological examination.

Cytoreductive surgery followed by chemotherapy with paclitaxel and/or platinum is considered the optimal and most effective treatment.


KEY WORDS: Ovary carcinosarcoma, ovary tumor.

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